Research profile · Oral Capsules
Tesofensine
Triple monoamine reuptake inhibitor
Available as: 500mcg
Overview
A small molecule that blocks the reuptake of noradrenaline, dopamine and serotonin, originally developed for Parkinson's and Alzheimer's disease.
Mechanism
Raises monoamine levels in the brain, reducing appetite and increasing energy expenditure.
Research highlights
- Phase 2 obesity trial: dose-dependent weight loss over 24 weeks.
- Raises heart rate, which has limited its development.
Compound data
- Type
- Small molecule