Research profile ยท Neuro & Cognitive
PT-141
Melanocortin receptor agonist (bremelanotide)
Available as: 10mg
Overview
A cyclic heptapeptide derived from melanotan-2. Approved in the US (Vyleesi) for hypoactive sexual desire disorder in premenopausal women.
Mechanism
Activates MC4R (and MC3R) in the central nervous system, acting on pathways of sexual desire rather than on blood flow.
Research highlights
- Phase 3 RECONNECT trials: improved sexual desire and reduced related distress versus placebo.
Compound data
- Length
- 7 amino acids (cyclic)
- Also known as
- Bremelanotide