Research profile · Repair & Recovery
Humanin
Mitochondrial-derived peptide
Available as: 10mg
Overview
A 24-amino-acid peptide encoded in the mitochondrial 16S rRNA gene, discovered in 2001 for protecting neurons against Alzheimer's-related insults.
Mechanism
Acts both inside cells (blocking the pro-apoptotic protein Bax) and through surface receptors, including a gp130-containing receptor complex.
Research highlights
- Protected neuronal cells from death caused by familial Alzheimer's disease genes and amyloid-β.
- Improved insulin sensitivity in rodent models.
- Circulating levels decline with age.
Compound data
- Length
- 24 amino acids