Research profile ยท Nootropics
Allopregnanolone
Neurosteroid
Available as: 500mg
Overview
A metabolite of progesterone produced in the brain. An intravenous formulation (brexanolone) was approved for postpartum depression.
Mechanism
A positive allosteric modulator of GABA-A receptors, including extrasynaptic receptors responsible for tonic inhibition.
Research highlights
- Rapid antidepressant effects in postpartum depression trials.
- Studied for neuroprotection and neurogenesis in Alzheimer's models.
Compound data
- Type
- Neurosteroid